[HTML][HTML] Targeting the Wnt signaling pathway in liver fibrosis for drug options: an update
Liver fibrosis is a life-threatening disease, with challenging morbidity and mortality for
healthcare systems worldwide. It imparts an enormous economic burden to societies …
healthcare systems worldwide. It imparts an enormous economic burden to societies …
Scar management in burn injuries using drug delivery and molecular signaling: current treatments and future directions
In recent decades, there have been tremendous improvements in burn care that have
allowed patients to survive severe burn injuries that were once fatal. However, a major …
allowed patients to survive severe burn injuries that were once fatal. However, a major …
GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury
Although AMP-activated protein kinase (AMPK) is involved in regulating carbohydrate and
lipid metabolism, activated AMPK also plays an anti-inflammatory role in many cell …
lipid metabolism, activated AMPK also plays an anti-inflammatory role in many cell …
The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial pneumonia. The
disease pathophysiology is poorly understood and the etiology remains unclear. Recent …
disease pathophysiology is poorly understood and the etiology remains unclear. Recent …
[HTML][HTML] Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases
E Beurel - Frontiers in molecular neuroscience, 2011 - frontiersin.org
Elevated markers of neuroinflammation have been found to be associated with many
psychiatric and neurodegenerative diseases, such as mood disorders, Alzheimer's disease …
psychiatric and neurodegenerative diseases, such as mood disorders, Alzheimer's disease …
Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses
M Baril, S Es-Saad, L Chatel-Chaix, K Fink… - PLoS …, 2013 - journals.plos.org
To identify new regulators of antiviral innate immunity, we completed the first genome-wide
gene silencing screen assessing the transcriptional response at the interferon-β (IFNB1) …
gene silencing screen assessing the transcriptional response at the interferon-β (IFNB1) …
CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia
S Chen, M Rong, A Platteau, D Hehre… - … of Physiology-Lung …, 2011 - journals.physiology.org
The pathological hallmarks of bronchopulmonary dysplasia (BPD), one of the most common
long-term pulmonary complications associated with preterm birth, include arrested …
long-term pulmonary complications associated with preterm birth, include arrested …
Glycogen synthase kinase‐3 (GSK‐3) regulates TGF‐β1‐induced differentiation of pulmonary fibroblasts
HA Baarsma, LHJM Engelbertink… - British journal of …, 2013 - Wiley Online Library
Background Chronic lung diseases such as asthma, COPD and pulmonary fibrosis are
characterized by abnormal extracellular matrix (ECM) turnover. TGF‐β is a key mediator …
characterized by abnormal extracellular matrix (ECM) turnover. TGF‐β is a key mediator …
Cellular Distribution of Secreted Phospholipase A2 in Lungs of IPF Patients and Its Inhibition in Bleomycin-Induced Pulmonary Fibrosis in Mice
A Jaiswal, R Rehman, J Dutta, S Singh, A Ray… - Cells, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a very poor prognosis as it
has a 2.5 to 5 years mean survival after proper diagnosis. Even nintedanib and pirfenidone …
has a 2.5 to 5 years mean survival after proper diagnosis. Even nintedanib and pirfenidone …
[HTML][HTML] Drug Repurposing for Targeting Acute Leukemia with KMT2A (MLL)—Gene Rearrangements
A Tsakaneli, O Williams - Frontiers in Pharmacology, 2021 - frontiersin.org
The treatment failure rates of acute leukemia with rearrangements of the Mixed Lineage
Leukemia (MLL) gene highlight the need for novel therapeutic approaches. Taking into …
Leukemia (MLL) gene highlight the need for novel therapeutic approaches. Taking into …