A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

Not all vertebrates share the familiar system of XX: XY sex determination seen in mammals.
In the chicken and other birds, sex is determined by a ZZ: ZW sex chromosome system …

The role of Anti-Müllerian hormone (Amh) during gonad development has been studied
extensively in mammals, but is less well understood in other vertebrates. In male …

In mammals, both testis and ovary arise from a sexually undifferentiated precursor, the
genital ridge, which first appears during mid-gestation as a thickening of the coelomic …

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory
regions of numerous genes. In vertebrates, these motifs are bound by one of six factors …

Blepharophimosis ptosis epicanthus inversus syndrome (BPES) is a human disorder caused
by mutations in the forkhead transcription factor gene FOXL2 and is characterized by facial …

Mutations in the forkhead transcription factor gene FOXL2 are involved in ovarian failure,
which occurs in human BPES syndrome. This syndrome presents a sexually dimorphic …

DMRT1 encodes a conserved transcription factor with an essential role in gonadal function.
In the chicken, DMRT1 in located on the Z sex chromosome and is currently the best …

Early differentiation in rainbow trout gonads was investigated by expression profiling and in
situ hybridization (ISH). Expression of cyp19a1 and fst in females and sox9a1 in males were …

We have previously shown that hexarelin, a novel GH-releasing peptide (GHRP), is able to
elicit GH release when administered iv, sc or by mouth and that it is a more potent GH …