Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

Activation of the androgen receptor is crucial for prostate cancer growth at all points of the
illness. Current therapies targeting the androgen receptor, including androgen-depletion …

Androgen deprivation therapy is the major treatment for advanced prostate cancer (PCa).
However, it is a temporary remission, and the patients almost inevitably develop hormone …

Androgen receptor (AR) is closely associated with a group of hormone‐related diseases
including the cancers of prostate, breast, ovary, pancreas, etc and anabolic deficiencies …

Anabolic androgenic steroids (AAS) are substances with androgenic and anabolic
characteristics. Among the many side effects of hormone therapy with AAS, the following …

The estimation of the correct binding mode and affinity of a ligand into a target protein using
computational methods is challenging. However, docking can introduce poses from which …

Androgen receptor (AR) agonists have strong endocrine disrupting effects in fish. Most
studies mainly investigate AR binding capacity using human AR in vitro. However, there is …

The farnesoid X receptor (FXR), a member of the nuclear hormone receptor family, plays
important roles in the regulation of bile acid and cholesterol homeostasis, glucose …

Occluded ligand-binding pockets (LBP) such as those found in nuclear receptors (NR) and
G-protein coupled receptors (GPCR) represent a significant opportunity and challenge for …