Poor water-solubility remains a typical property of drug candidates in pharmaceutical
development pipelines today. Various processes have been developed to increase the …

Hot-melt extrusion (HME) is a promising technology for the production of new chemical
entities in the developmental pipeline and for improving products already on the market. In …

Contemporary pharmaceutical pipelines are often highly populated with poorly water-
soluble drug candidates necessitating novel formulation technologies to provide dosage …

This article is intended to combine literature on cocrystallization–a tool for enhancing the
solubility and for improving the physicochemical properties of an API (an API is the molecule …

Amorphous solid dispersion (ASD) can accelerate a project by improving dissolution rate
and solubility, offering dose escalation flexibility and excipient acceptance for toxicology …

Poor water-solubility is a common characteristic of drug candidates in pharmaceutical
development pipelines today. Various processes have been developed to increase the …

Pharmaceutical research, whether industrial or academic, has attempted to adopt
approaches most efficient for the development of innovations. With the abundance of …

The processing parameters for HME have been evaluated and the impact of solid state
intermolecular drug–polymer interactions on supersaturation has been investigated. Poorly …

Supersaturating drug delivery systems (SDDS) hold the promise of enabling intestinal
absorption for difficult-to-formulate, poorly soluble drug candidates based on a design …

Melt extrusion (ME) over recent years has found widespread application as a viable drug
delivery option in the drug development process. ME applications include taste masking …