Cell sheet approach for tissue engineering and regenerative medicine
After the biotech medicine era, regenerative medicine is expected to be an advanced
medicine that is capable of curing patients with difficult-to-treat diseases and physically …
medicine that is capable of curing patients with difficult-to-treat diseases and physically …
Design considerations for macroencapsulation devices for stem cell derived islets for the treatment of type 1 diabetes
Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1
Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation …
Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation …
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells
Despite advances in the differentiation of insulin-producing cells from human embryonic
stem cells, the generation of mature functional β cells in vitro has remained elusive. To …
stem cells, the generation of mature functional β cells in vitro has remained elusive. To …
[图书][B] Handbook of encapsulation and controlled release
M Mishra - 2015 - books.google.com
Written at a level comprehensible to non-experts, this handbook covers the current state of
encapsulation and controlled released technologies, presenting the fundamental processes …
encapsulation and controlled released technologies, presenting the fundamental processes …
Transplantation of human islets without immunosuppression
B Ludwig, A Reichel, A Steffen… - Proceedings of the …, 2013 - National Acad Sciences
Transplantation of pancreatic islets is emerging as a successful treatment for type-1
diabetes. Its current stringent restriction to patients with critical metabolic lability is justified …
diabetes. Its current stringent restriction to patients with critical metabolic lability is justified …
PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids
CC Lin, A Raza, H Shih - Biomaterials, 2011 - Elsevier
Hydrogels provide three-dimensional frameworks with tissue-like elasticity and high
permeability for culturing therapeutically relevant cells or tissues. While recent research …
permeability for culturing therapeutically relevant cells or tissues. While recent research …
A predictive computational platform for optimizing the design of bioartificial pancreas devices
The delivery of encapsulated islets or stem cell-derived insulin-producing cells (ie,
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids
Native pancreatic islets interact with neighboring cells by establishing three-dimensional
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
Enhanced oxygen supply improves islet viability in a new bioartificial pancreas
U Barkai, GC Weir, CK Colton, B Ludwig… - Cell …, 2013 - journals.sagepub.com
The current epidemic of diabetes with its overwhelming burden on our healthcare system
requires better therapeutic strategies. Here we present a promising novel approach for a …
requires better therapeutic strategies. Here we present a promising novel approach for a …
Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival
H Komatsu, C Cook, CH Wang, L Medrano, H Lin… - PloS one, 2017 - journals.plos.org
Background Type 1 diabetes is an autoimmune disease that destroys insulin-producing beta
cells in the pancreas. Pancreatic islet transplantation could be an effective treatment option …
cells in the pancreas. Pancreatic islet transplantation could be an effective treatment option …