Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

The term interferon describes a family of proteins consisting of three major types (I, II, III)
which differ in their primary protein sequences, cognate receptors, genetic loci, and cell …

Gene regulatory changes are thought to be major factors driving species evolution, with
creation of new regulatory regions likely being instrumental in contributing to diversity …

Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders
with a complex etiology, which represent a clinical challenge due to their often therapy …

Background Multiple studies have shown that brain gene expression is disturbed in subjects
suffering from schizophrenia. However, disentangling disease effects from alterations …

Originally identified by their unusual ability to bind guanosine monophosphate (GMP)
nucleotide agarose, the guanylate-binding proteins (GBPs) were used extensively to …

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved
in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many …

The guanylate-binding proteins (GBPs) were among the first interferon (IFN)-stimulated
genes (ISGs) discovered, but until recently, little was known about their functions and even …

Guanylate-binding proteins (GBPs) belong to the dynamin family of large GTPases and
represent the major IFN-γ-induced proteins. Here we systematically investigated the …