Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs

I Nyamba, CB Sombie, M Yabre… - European Journal of …, 2024 - Elsevier
High solubility in water and physiological fluids is an indispensable requirement for the
pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well …

[HTML][HTML] Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective

M Rehman, N Tahir, MF Sohail, MU Qadri, SOD Duarte… - Pharmaceutics, 2024 - mdpi.com
Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous
medium with the help of a surfactant and enabling their absorption across the gut barrier …

Formulation and Evaluation of a Self-Microemulsifying Drug Delivery System of Raloxifene with Improved Solubility and Oral Bioavailability

MM Ansari, DK Vo, HI Choi, JS Ryu, Y Bae, NI Bukhari… - Pharmaceutics, 2023 - mdpi.com
Poor aqueous solubility and dissolution limit the oral bioavailability of Biopharmaceutics
Classification System (BCS) class II drugs. In this study, we aimed to improve the aqueous …

Recent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: A comparative study of machine learning and systems …

H Kavoni, ISP Savizi, NE Lewis… - Biotechnology Advances, 2024 - Elsevier
The production of monoclonal antibodies (mAbs) using Chinese Hamster Ovary (CHO) cells
has revolutionized the treatment of numerous diseases, solidifying their position as a …

[HTML][HTML] Evaluating efficiency in water and sewerage services: An integrated DEA approach with DOE and PCA

K Pishini, O Abdolazimi, D Shishebori… - Science of The Total …, 2025 - Elsevier
Evaluating the performance of service organizations like Water and Sewerage companies is
essential for optimal operations, high-quality service, and cost efficiency. This paper …

Development of a Composite Hydrogel Containing Statistically Optimized PDGF-Loaded Polymeric Nanospheres for Skin Regeneration: In Vitro Evaluation and Stem …

R Hazrati, E Alizadeh, S Soltani, P Keyhanvar… - ACS …, 2024 - ACS Publications
Platelet-derived growth factor-BB (PDGF-BB) is a polypeptide growth factor generated by
platelet granules faced to cytokines. It plays a role in forming and remodeling various tissue …

Preparation of Self-microemulsion Solids of Kaempferia galanga (L.) Volatile Oil and Its Effect on Rats with Gastric Ulcer

D Liu, R Liu, Z Zhuang, B Yao, C Qin, F Ma, J Shi - AAPS PharmSciTech, 2023 - Springer
Kaempferia galanga volatile oil (KVO), the main effective component of the medicinal plant
Kaempferia galanga L., possesses a variety of pharmacological activities such as anti …

Oral delivery of posaconazole-loaded phospholipid-based nanoformulation: Preparation and optimization using design of experiments, machine learning, and …

F Bayat, S Dadashzadeh, R Aboofazeli… - International Journal of …, 2024 - Elsevier
Phospholipid-based nanosystems show promising potentials for oral administration of
hydrophobic drugs. The study introduced a novel approach to optimize posaconazole …

Antiviral Properties of Essential Oil Mixture: Modulation of E7 and E2 Protein Pathways in Human Papillomavirus (HPV) Infection

B Uner, E Guler, ME Vicir, H Kayhan, N Atsu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Clove is used in Indian and Chinese traditional medicine
for viral diseases. Palmarosa essential oils have been traditionally used in India and …

Enhanced efficacy of Magnolia denudata essential oil in fish anesthesia using nanoemulsions and self-microemulsifying drug delivery systems

X Zeng, H Dong, X Zheng, J Zhang - Frontiers in Veterinary Science, 2024 - frontiersin.org
Introduction The use of plant essential oils as anesthetics for fish has gained increasing
attention, but ethanol, often used as a co-solvent, presents certain limitations. Recently …