Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs
I Nyamba, CB Sombie, M Yabre… - European Journal of …, 2024 - Elsevier
High solubility in water and physiological fluids is an indispensable requirement for the
pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well …
pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well …
[HTML][HTML] Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective
Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous
medium with the help of a surfactant and enabling their absorption across the gut barrier …
medium with the help of a surfactant and enabling their absorption across the gut barrier …
Formulation and Evaluation of a Self-Microemulsifying Drug Delivery System of Raloxifene with Improved Solubility and Oral Bioavailability
Poor aqueous solubility and dissolution limit the oral bioavailability of Biopharmaceutics
Classification System (BCS) class II drugs. In this study, we aimed to improve the aqueous …
Classification System (BCS) class II drugs. In this study, we aimed to improve the aqueous …
Recent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: A comparative study of machine learning and systems …
The production of monoclonal antibodies (mAbs) using Chinese Hamster Ovary (CHO) cells
has revolutionized the treatment of numerous diseases, solidifying their position as a …
has revolutionized the treatment of numerous diseases, solidifying their position as a …
[HTML][HTML] Evaluating efficiency in water and sewerage services: An integrated DEA approach with DOE and PCA
K Pishini, O Abdolazimi, D Shishebori… - Science of The Total …, 2025 - Elsevier
Evaluating the performance of service organizations like Water and Sewerage companies is
essential for optimal operations, high-quality service, and cost efficiency. This paper …
essential for optimal operations, high-quality service, and cost efficiency. This paper …
Development of a Composite Hydrogel Containing Statistically Optimized PDGF-Loaded Polymeric Nanospheres for Skin Regeneration: In Vitro Evaluation and Stem …
Platelet-derived growth factor-BB (PDGF-BB) is a polypeptide growth factor generated by
platelet granules faced to cytokines. It plays a role in forming and remodeling various tissue …
platelet granules faced to cytokines. It plays a role in forming and remodeling various tissue …
Preparation of Self-microemulsion Solids of Kaempferia galanga (L.) Volatile Oil and Its Effect on Rats with Gastric Ulcer
D Liu, R Liu, Z Zhuang, B Yao, C Qin, F Ma, J Shi - AAPS PharmSciTech, 2023 - Springer
Kaempferia galanga volatile oil (KVO), the main effective component of the medicinal plant
Kaempferia galanga L., possesses a variety of pharmacological activities such as anti …
Kaempferia galanga L., possesses a variety of pharmacological activities such as anti …
Oral delivery of posaconazole-loaded phospholipid-based nanoformulation: Preparation and optimization using design of experiments, machine learning, and …
F Bayat, S Dadashzadeh, R Aboofazeli… - International Journal of …, 2024 - Elsevier
Phospholipid-based nanosystems show promising potentials for oral administration of
hydrophobic drugs. The study introduced a novel approach to optimize posaconazole …
hydrophobic drugs. The study introduced a novel approach to optimize posaconazole …
Antiviral Properties of Essential Oil Mixture: Modulation of E7 and E2 Protein Pathways in Human Papillomavirus (HPV) Infection
B Uner, E Guler, ME Vicir, H Kayhan, N Atsu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Clove is used in Indian and Chinese traditional medicine
for viral diseases. Palmarosa essential oils have been traditionally used in India and …
for viral diseases. Palmarosa essential oils have been traditionally used in India and …
Enhanced efficacy of Magnolia denudata essential oil in fish anesthesia using nanoemulsions and self-microemulsifying drug delivery systems
Introduction The use of plant essential oils as anesthetics for fish has gained increasing
attention, but ethanol, often used as a co-solvent, presents certain limitations. Recently …
attention, but ethanol, often used as a co-solvent, presents certain limitations. Recently …