Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which is involved in …

Background Prognostic biomarkers remain a focus in breast cancer during last decades.
More reliable predictors to adequately characterize the prognosis of breast cancer are …

Integrated bioinformatics and statistical approaches are now playing the vital role in
identifying potential molecular biomarkers more accurately in presence of huge number of …

Background OAS1 expression in pancreatic cancer has been confirmed by many studies.
However, the prognostic value and mechanism of OAS1 in pancreatic cancer have not been …

The cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers responsible for
translating extracellular signals to intracellular biological responses in both normal and …

Metastasis is the major cause of cancer-related death in patients with colorectal cancer.
Although inducible nitric oxide synthase (iNOS) is a crucial regulator of cancer development …

Purpose: By catalyzing cGMP hydrolysis, phosphodiesterase (PDE) 5 is a critical regulator of
its concentration and effects in different (patho) physiologic processes, including cancers. As …

Platinum resistance is one of the major concerns in ovarian cancer treatment. Recent
evidence shows the critical role of epithelial–mesenchymal transition (EMT) in this …

Background Metastasis is a leading cause of breast cancer mortality. The induction of
epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step …