Stroke and Alzheimer's disease (AD) are cerebral pathologies with high socioeconomic
impact that can occur together and mutually interact. Vascular factors predisposing to …

The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for
the preclinical assessment of new treatment strategies for Alzheimer's disease. However, the …

Positron emission tomography (PET), a medical imaging technique allowing for studies of
the living human brain, has gained an important role in clinical trials of novel drugs against …

Introduction Performance of the amyloid tracer [18 F] flutemetamol was evaluated against
three pathology standard of truth (SoT) measures including neuritic plaques (CERAD …

Deposition of beta-amyloid (Aβ) deposits is one major histopathological hallmark of
Alzheimer's disease (AD). Here, we introduce volumetric multi-spectral optoacoustic …

In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a
series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction …

Abstract Fluselenamyl (5), a novel planar benzoselenazole shows traits desirable of
enabling noninvasive imaging of Aβ pathophysiology in vivo; labeling of both diffuse (an …

Abstract Background In the US, EU and elsewhere, basic clinical research studies with
positron emission tomography (PET) radiotracers that are generally recognized as safe and …

Animal models of Alzheimer's disease amyloidosis that recapitulate cerebral amyloid-beta
pathology have been widely used in preclinical research and have greatly enabled the …

Objective: We evaluated the effects of bone marrow–derived mesenchymal stem cells in a
model of Alzheimer's disease using serial [18F] Florbetaben positron emission tomography …