Synaptic neurexin complexes: a molecular code for the logic of neural circuits
TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …
information, thereby connecting neurons into millions of overlapping and interdigitated …
Genetics of glutamate and its receptors in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …
deficits in social interaction skills, impaired communication, and repetitive and restricted …
Neuroligin-3: a circuit-specific synapse organizer that shapes normal function and autism spectrum disorder-associated dysfunction
M Uchigashima, A Cheung, K Futai - Frontiers in Molecular …, 2021 - frontiersin.org
Chemical synapses provide a vital foundation for neuron-neuron communication and overall
brain function. By tethering closely apposed molecular machinery for presynaptic …
brain function. By tethering closely apposed molecular machinery for presynaptic …
The neuroligins and the synaptic pathway in Autism Spectrum Disorder
L Trobiani, M Meringolo, T Diamanti, Y Bourne… - Neuroscience & …, 2020 - Elsevier
The genetics underlying autism spectrum disorder (ASD) is complex and heterogeneous,
and de novo variants are found in genes converging in functional biological processes …
and de novo variants are found in genes converging in functional biological processes …
Autism and schizophrenia-associated CYFIP1 regulates the balance of synaptic excitation and inhibition
Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and
neurodevelopmental disorders, but the underlying genetic etiology remains poorly …
neurodevelopmental disorders, but the underlying genetic etiology remains poorly …
Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses
The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters
that are aligned with presynaptic release sites is essential for the high fidelity of synaptic …
that are aligned with presynaptic release sites is essential for the high fidelity of synaptic …
Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number
Abstract Neuroligin-3 (Nlgn3) is an autism-associated cell-adhesion molecule that interacts
with neurexins and is robustly expressed in both neurons and astrocytes. Neuronal Nlgn3 is …
with neurexins and is robustly expressed in both neurons and astrocytes. Neuronal Nlgn3 is …
Neuroligin-4 regulates excitatory synaptic transmission in human neurons
The autism-associated synaptic-adhesion gene Neuroligin-4 (NLGN4) is poorly conserved
evolutionarily, limiting conclusions from Nlgn4 mouse models for human cells. Here, we …
evolutionarily, limiting conclusions from Nlgn4 mouse models for human cells. Here, we …
Synaptotagmin-7-mediated asynchronous release boosts high-fidelity synchronous transmission at a central synapse
F Luo, TC Südhof - Neuron, 2017 - cell.com
Synchronous release triggered by Ca 2+ binding to synaptotagmin-1,-2, or-9 is thought to
drive fast synaptic transmission, whereas asynchronous release induced by Ca 2+ binding …
drive fast synaptic transmission, whereas asynchronous release induced by Ca 2+ binding …
Neurexins cluster Ca2+ channels within the presynaptic active zone
F Luo, A Sclip, M Jiang, TC Südhof - The EMBO journal, 2020 - embopress.org
To achieve ultrafast neurotransmission, neurons assemble synapses with highly organized
presynaptic and postsynaptic nanomachines that are aligned by synaptic adhesion …
presynaptic and postsynaptic nanomachines that are aligned by synaptic adhesion …