Hemoglobin-derived peptides as novel type of bioactive signaling molecules
Most bioactive peptides are generated by proteolytic cleavage of large precursor proteins
followed by storage in secretory vesicles from where they are released upon cell stimulation …
followed by storage in secretory vesicles from where they are released upon cell stimulation …
Anticonvulsant neuropeptides as drug leads for neurological diseases
CR Robertson, SP Flynn, HS White, G Bulaj - Natural Product Reports, 2011 - pubs.rsc.org
Covering: 1995 to 2010 Anticonvulsant neuropeptides are best known for their ability to
suppress seizures and modulate pain pathways. Galanin, neuropeptide Y, somatostatin …
suppress seizures and modulate pain pathways. Galanin, neuropeptide Y, somatostatin …
[图书][B] Retrometabolic drug design and targeting
N Bodor, P Buchwald - 2012 - books.google.com
Innovative approach to drug design that's more likely to result in an approvable drug product
Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft …
Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft …
Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia
MMB Ribeiro, ART Pinto, MM Domingues… - Molecular …, 2011 - ACS Publications
The pharmaceutical potential of natural analgesic peptides is mainly hampered by their
inability to cross the blood–brain barrier, BBB. Increasing peptide–cell membrane affinity …
inability to cross the blood–brain barrier, BBB. Increasing peptide–cell membrane affinity …
[HTML][HTML] Pharmacological potential of the endogenous dipeptide kyotorphin and selected derivatives
J Perazzo, MARB Castanho, S Sá Santos - Frontiers in pharmacology, 2017 - frontiersin.org
The endogenous peptide kyotorphin (KTP) has been extensively studied since it was
discovered in 1979. The dipeptide is distributed unevenly over the brain but the majority is …
discovered in 1979. The dipeptide is distributed unevenly over the brain but the majority is …
[HTML][HTML] Review of kyotorphin research: a mysterious opioid analgesic dipeptide and its molecular, physiological, and pharmacological characteristics
H Ueda - Frontiers in Medical Technology, 2021 - frontiersin.org
Tyrosine-arginine (kyotorphin), an opioid analgesic dipeptide, was discovered more than 40
years ago in 1979. The evidence accumulated during this period has established the …
years ago in 1979. The evidence accumulated during this period has established the …
Retrometabolism‐based drug design and targeting
N Bodor, P Buchwald - Burger's medicinal chemistry and drug …, 2003 - Wiley Online Library
Retrometabolic drug design (RMDD) approaches are systematic methodologies aimed to
design safe compounds with an improved therapeutic index. RMDDs thoroughly integrate …
design safe compounds with an improved therapeutic index. RMDDs thoroughly integrate …
Moderate protective effect of Kyotorphin against the late consequences of intracerebroventricular streptozotocin model of Alzheimer's disease
H Angelova, D Pechlivanova, E Krumova… - Amino Acids, 2019 - Springer
The established decrease in the level of endogenous kyotorphin (KTP) into the
cerebrospinal fluid of patients with an advanced stage of Alzheimer's disease (AD) and the …
cerebrospinal fluid of patients with an advanced stage of Alzheimer's disease (AD) and the …
[HTML][HTML] Amidated and ibuprofen-conjugated kyotorphins promote neuronal rescue and memory recovery in cerebral hypoperfusion dementia model
S Sá Santos, SM Santos, ART Pinto… - Frontiers in aging …, 2016 - frontiersin.org
Chronic brain ischemia is a prominent risk factor for neurological dysfunction and
progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral …
progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral …
[HTML][HTML] Neuropeptide kyotorphin (tyrosyl-arginine) has decreased levels in the cerebro-spinal fluid of Alzheimer's disease patients: potential diagnostic and …
SM Santos, L Garcia-Nimo, S Sá Santos… - Frontiers in aging …, 2013 - frontiersin.org
In Alzheimer's disease (AD), besides the characteristic deterioration of memory, studies also
point to a higher pain tolerance in spite of sensibility preservation. A change in the normal …
point to a higher pain tolerance in spite of sensibility preservation. A change in the normal …