None of the other existing preclinical and clinical AAV studies has demonstrated any severe
adverse events. 13, 17, 21–23 Associated LQWHJUDWLRQ VLWH VWXGLHV DOVR GLG …

In a recent editorial in Molecular Therapy, Büning and Schmidt1 discussed the role of gene
therapy vectors based on adeno-associated viruses (AAVs) in the development of liver …

Nuclear DNA viruses simultaneously access cellular factors that aid their life cycle while
evading inhibitory factors by localizing to distinct nuclear sites. Adeno-associated viruses …

Highlights•Nuclear architecture and nuclear pore trafficking strongly influence HIV
integration.•wtAAV integration targets genomic regions bearing a Rep binding site and trs …

Adeno-associated virus (AAV) is a small human Dependovirus whose low immunogenicity
and capacity for long-term persistence have led to its widespread use as vector for gene …

Adeno-associated virus (AAV) producer cell lines are created via transfection of HeLaS3
cells with a single plasmid containing three components (the vector sequence, the AAV rep …

Abstract The Rep68 protein from Adeno-Associated Virus (AAV) is a multifunctional SF3
helicase that performs most of the DNA transactions required for the viral life cycle. During …

The life cycle of the human parvovirus adeno-associated virus (AAV) is orchestrated by four
Rep proteins. The large Rep proteins, Rep78 and Rep68, are remarkably multifunctional …

Endonucleases of the HUH family are specialized in processing single-stranded DNA in a
variety of evolutionarily highly conserved biological processes related to mobile genetic …

Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-
1). This activity has been linked to the helicase-and DNA-binding domains of the …