Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

The Notch signaling pathway regulates many aspects of cancer biology. Most attention has
been given to its role in the transformed cell. However, it is now clear that cancer …

The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …

After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …

Bone metastases (BM) are a common complication of cancer, whose management often
requires a multidisciplinary approach. Despite the recent therapeutic advances, patients with …

Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality
of life of myeloma patients, and it affects dramatically their morbidity and mortality. The basis …

Bone metastasis is a major cause of morbidity in persons with cancer. Complications include
pain, impaired mobility, pathological fracture, spinal cord compression, cranial nerve …

Many cancer types metastasize to bone. This propensity may be a product of genetic traits of
the primary tumour in some cancers. Upon arrival, cancer cells establish interactions with …

A substantial amount patients with cancer will develop bone metastases, with 70% of
metastatic prostate and breast cancer patients harboring bone metastasis. Despite …