Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …
Engineering of MSC-derived exosomes: a promising cell-free therapy for osteoarthritis
J Cheng, Y Sun, Y Ma, Y Ao, X Hu, Q Meng - Membranes, 2022 - mdpi.com
Osteoarthritis (OA) is characterized by progressive cartilage degeneration with increasing
prevalence and unsatisfactory treatment efficacy. Exosomes derived from mesenchymal …
prevalence and unsatisfactory treatment efficacy. Exosomes derived from mesenchymal …
Three dimensional microcarrier system in mesenchymal stem cell culture: a systematic review
Stem cell-based regenerative medicine is a promising approach for tissue reconstruction.
However, a large number of cells are needed in a typical clinical study, where conventional …
However, a large number of cells are needed in a typical clinical study, where conventional …
Emerging trends in biodegradable microcarriers for therapeutic applications
HK Handral, TA Wyrobnik, ATL Lam - Polymers, 2023 - mdpi.com
Microcarriers (MCs) are adaptable therapeutic instruments that may be adjusted to specific
therapeutic uses, making them an appealing alternative for regenerative medicine and drug …
therapeutic uses, making them an appealing alternative for regenerative medicine and drug …
Culture substrates for improved manufacture of mesenchymal stromal cell therapies
G Doron, JS Temenoff - Advanced Healthcare Materials, 2021 - Wiley Online Library
Recent developments in mesenchymal stromal cell (MSC) therapies have increased the
demand for tools to improve their manufacture, including the selection of optimal culture …
demand for tools to improve their manufacture, including the selection of optimal culture …
Mapping the microcarrier design pathway to modernise clinical mesenchymal stromal cell expansion
Microcarrier expansion systems show exciting potential to revolutionise mesenchymal
stromal cell (MSC)-based clinical therapies by providing an opportunity for economical large …
stromal cell (MSC)-based clinical therapies by providing an opportunity for economical large …
Aligned skeletal muscle assembly on a biofunctionalized plant leaf scaffold
Decellularized plant scaffolds have drawn attention as alternative tissue culture platforms
due to their wide accessibility, biocompatibility, and diversity of innate microstructures …
due to their wide accessibility, biocompatibility, and diversity of innate microstructures …
Volumetric imaging of human mesenchymal stem cells (hMSCs) for non-destructive quantification of 3D cell culture growth
The adoption of cell-based therapies into the clinic will require tremendous large-scale
expansion to satisfy future demand, and bioreactor-microcarrier cultures are best suited to …
expansion to satisfy future demand, and bioreactor-microcarrier cultures are best suited to …
Xeno-free bioreactor culture of human mesenchymal stromal cells on chemically defined microcarriers
JD Krutty, K Koesser, S Schwartz, J Yun… - ACS Biomaterials …, 2021 - ACS Publications
Human mesenchymal stromal cells (hMSC), also called mesenchymal stem cells, are adult
cells that have demonstrated their potential in therapeutic applications, highlighted by their …
cells that have demonstrated their potential in therapeutic applications, highlighted by their …
Polymer-coated magnetic microspheres conjugated with growth factor receptor binding peptides enable cell sorting
The separation and sorting of human cells is an important step in the bioprocessing of cell-
based therapeutics. Heterogeneous mixtures of cells must be sorted to isolate the desired …
based therapeutics. Heterogeneous mixtures of cells must be sorted to isolate the desired …