Cannabis was extensively used as a medicine throughout the developed world in the
nineteenth century but went into decline early in the twentieth century ahead of its …

In the early 2000s in Europe and shortly thereafter in the USA, it was reported that
'legal'forms of marijuana were being sold under the name K2 and/or Spice. Active …

The Cannabinoid CB1 Receptor (CB1R) is involved in a variety of physiological pathways
and has long been considered a golden target for therapeutic manipulation. A large body of …

Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication
development for treating substance use disorders (SUDs). Early studies indicated that …

Substance use disorder (SUD) is a major public health crisis worldwide, and effective
treatment options are limited. During the past 2 decades, researchers have investigated the …

In the reward circuitry of the brain, α-7-nicotinic acetylcholine receptors (α7nAChRs)
modulate effects of Δ 9-tetrahydrocannabinol (THC), marijuana's main psychoactive …

Background: Multiple studies suggest a pivotal role of the endocannabinoid system in
regulating the reinforcing effects of various substances of abuse. Rimonabant, a CB1 …

Presently, obesity is one of the major health problems in the developed as well as
developing countries due to lack of physical work and increasing sedentary life style …

Nicotine, the main psychoactive component of tobacco, and (−)− Δ 9-tetrahydrocannabinol
(THC), the main psychoactive ingredient in cannabis, play major roles in tobacco and …

Background: Disturbances in the regulation of reward and aversion in the brain may
underlie disorders such as obesity and eating disorders. We previously showed that the …