Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …

Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishing array of complex
and chemically challenging reactions across all domains of life. Of approximately 114,000 of …

The radical SAM enzymes—also referred to as the AdoMet radical enzymes—are a newly
identified enzyme superfamily1 capable of catalyzing radical chemistry similar to, but more …

Pyruvate formate-lyase activating enzyme generates a stable and catalytically essential
glycyl radical on G734 of pyruvate formate-lyase via the direct, stereospecific abstraction of a …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

The numerous post-transcriptional modifications of tRNA play a crucial role in tRNA function.
While most modifications are introduced to tRNA independently, several sets of …

A vast number of enzymes are now known to belong to a superfamily known as radical SAM,
which all contain a [4Fe–4S] cluster ligated by three cysteine residues. The remaining …

FeS cluster biogenesis is an essential process in virtually all forms of life. Complex protein
machineries that are conserved from bacteria through higher eukaryotes facilitate assembly …

The glycyl radical enzyme activating enzymes (GRE–AEs) are a group of enzymes that
belong to the radical S-adenosylmethionine (SAM) superfamily and utilize a [4Fe–4S] cluster …

Adenosine is undoubtedly an ancient biological molecule that is a component of many
enzyme cofactors: ATP, FADH, NAD (P) H, and coenzyme A, to name but a few, and, of …