The past decade has seen a major increase in the study of noncoding RNAs (ncRNAs).
However, there remains a great deal of confusion and debate over the levels of functionality …

Recent transcriptome analyses show that substantial proportions of eukaryotic genomes can
be copied into RNAs, many of which do not encode protein sequences. However, cells have …

Polycomb/Trithorax group response elements (PRE/TREs) are fascinating chromosomal
pieces. Just a few hundred base pairs long, these elements can remember and maintain the …

Polycomb group genes (PcG) encode a group of about 16 proteins that were first identified
in Drosophila as repressors of homeotic genes. PcG proteins are present in all metazoans …

Polycomb group (PcG) proteins are conserved regulatory proteins that repress transcription
of particular target genes in animals and plants. Studies over the past decade have …

Polycomb group (PcG) proteins form conserved regulatory complexes that modify chromatin
to repress transcription. Here, we report genome-wide binding profiles of PhoRC, the …

Polycomb group (PcG) proteins are able to maintain the memory of silent transcriptional
states of homeotic genes throughout development. In Drosophila, they form multimeric …

A long-standing mystery in the field of Polycomb and Trithorax regulation is how these
proteins, which are highly conserved between flies and mammals, can regulate several …

The Polycomb gene was discovered 60 years ago as a mutation inducing a particular
homeotic phenotype. Subsequent work showed that Polycomb is a general repressor of …

Abstract The Polycomb group (PcG) proteins are fundamental epigenetic regulators that
control the repressive state of target genes in multicellular organisms. One of the open …