Carotid body chemoreceptors: physiology, pathology, and implications for health and disease
R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
Sympathetic activation: a potential link between comorbidities and COVID‐19
A Porzionato, A Emmi, S Barbon… - The FEBS …, 2020 - Wiley Online Library
In coronavirus disease 2019 (COVID‐19), higher morbidity and mortality are associated with
age, male gender, and comorbidities, such as chronic lung diseases, cardiovascular …
age, male gender, and comorbidities, such as chronic lung diseases, cardiovascular …
Therapeutic potential of intermittent hypoxia: a matter of dose
A Navarrete-Opazo, GS Mitchell - American Journal of …, 2014 - journals.physiology.org
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …
triggers a bewildering array of both detrimental and beneficial effects in multiple …
Hypoxia-inducible factors and obstructive sleep apnea
NR Prabhakar, YJ Peng… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA), a
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …
[HTML][HTML] Peripheral chemoreceptors: function and plasticity of the carotid body
P Kumar, NR Prabhakar - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …
20th century. Following these seminal discoveries, research into carotid body mechanisms …
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
NR Prabhakar, GL Semenza - Physiological reviews, 2012 - journals.physiology.org
Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological
systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of …
systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of …
Mechanisms of vascular damage in obstructive sleep apnea
M Kohler, JR Stradling - Nature Reviews Cardiology, 2010 - nature.com
Obstructive sleep apnea (OSA) is characterized by repetitive apnea–hypopnea cycles
during sleep, which are associated with oxygen desaturation and sleep disruption. Up to …
during sleep, which are associated with oxygen desaturation and sleep disruption. Up to …
[HTML][HTML] The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities
It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial
pressure levels. Sympathetic oscillations coupled to the respiratory activity have been …
pressure levels. Sympathetic oscillations coupled to the respiratory activity have been …
Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation
JF Garvey, CT Taylor… - European Respiratory …, 2009 - Eur Respiratory Soc
There is increasing evidence that intermittent hypoxia plays a role in the development of
cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of …
cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of …