Phosphorylated tau in Alzheimer's disease and other tauopathies
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
The neuropathology and cerebrovascular mechanisms of dementia
L Raz, J Knoefel, K Bhaskar - Journal of Cerebral Blood Flow …, 2016 - journals.sagepub.com
The prevalence of dementia is increasing in our aging population at an alarming rate.
Because of the heterogeneity of clinical presentation and complexity of disease …
Because of the heterogeneity of clinical presentation and complexity of disease …
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
JD Rohrer, IOC Woollacott, KM Dick, E Brotherhood… - Neurology, 2016 - AAN Enterprises
Objective: To investigate serum neurofilament light chain (NfL) concentrations in
frontotemporal dementia (FTD) and to see whether they are associated with the severity of …
frontotemporal dementia (FTD) and to see whether they are associated with the severity of …
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross …
Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …
about a third of patients, the disease is caused by autosomal dominant genetic mutations …
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death
Summary Expanded GGGGCC (G4C2) nucleotide repeats within the C9ORF72 gene are the
most common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and …
most common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and …
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
KM Moore, J Nicholas, M Grossman… - The Lancet …, 2020 - thelancet.com
Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …
about a third of cases being genetic. Most of this genetic component is accounted for by …
Neuroimaging in dementia: more than typical Alzheimer disease
Alzheimer disease (AD) is the most common cause of dementia. The prevailing theory of the
underlying pathology assumes amyloid accumulation followed by tau protein aggregation …
underlying pathology assumes amyloid accumulation followed by tau protein aggregation …
Frontotemporal dementia, where do we stand? A narrative review
A Antonioni, EM Raho, P Lopriore, AP Pace… - International journal of …, 2023 - mdpi.com
Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …
The prevalence and incidence of frontotemporal dementia: a systematic review
BackgroundPopulation-based prevalence and incidence studies are essential for
understanding the burden of frontotemporal dementia (FTD). MethodsThe MEDLINE and …
understanding the burden of frontotemporal dementia (FTD). MethodsThe MEDLINE and …
A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex
We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …