Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors
(COXibs) inhibit the progression of endometrial cancer, ovarian cancer and cervical cancer …

Simple Summary Wnt has diverse regulatory roles at multiple cellular levels and numerous
targeting points, and aberrant Wnt signaling has crucial roles in carcinogenesis, metastasis …

In the present study, we reported the efficient synthesis of novel, heterocyclic, coumarin-
based pyrano-chromene derivatives, 2-amino-8-methyl-5-oxo-4-[2-(2-oxo-2H-chromen-3 …

Background The repurposing of FDA-approved drugs for anti-cancer therapies is appealing
due to their established safety profiles and pharmacokinetic properties and can be quickly …

An Efficient Synthesis of 4H-chromene Derivatives by a One-pot, Three-component Reaction
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Endometrial hyperplasia is a precursor to the most common gynecologic cancer diagnosed
in women. Apart from estrogenic induction, aberrant activation of the Wnt/β-catenin signal is …

The precise mechanism through which the two estrogen receptor subtypes, ERα and ERβ,
are linked to endometrial malignant progression is not fully understood. The aim of the …

This work aimed to produce novel heterocyclic compounds such as chromene, thieno [3, 2-f]
chromene, chromeno [5, 6-d] thiazole and quinoline derivatives. The newly synthesized …

Abstract Two 4H-chromene derivatives (1C and 1F) were synthesized by the
multicomponent condensation reactions (MCRs) and spectroscopically characterized. The 3 …

Background Prostaglandin E2 (PGE2) receptor 3 (EP3) regulates tumor cell proliferation,
migration, and invasion in numerous cancers. The role of EP3 as a prognostic biomarker in …