Immune-mediated inflammatory diseases (IMIDs) are responsible for substantial global
disease burden and associated health-care costs. Traditional models of research and …

Background The efficiencies that master protocol designs can bring to modern drug
development have seen their increased utilization in oncology. Growing interest has also …

Highlights•Key areas to be evaluated for the application of borrowing are an understanding
of the disease groups being studied, the drug mechanism of action, and the measurement …

Background: Drug development is often inefficient, costly and lengthy, yet it is essential for
evaluating the safety and efficacy of new interventions. Compared with other disease areas …

Randomized controlled clinical trials provide the gold standard for evidence generation in
relation to the effectiveness of a new treatment in medical research. Relevant information …

Umbrella and basket trials evaluate multiple experimental treatments, multiple diseases, or
both under a single trial infrastructure and protocol. There is a need to develop efficient …

In recent years, the use of master protocol design in clinical trials has received much
attention. Master protocol design, which includes basket, umbrella, and platform design, has …