The Trypanosoma cruzi genome contains the most widely expanded content (∼ 12,000
genes) of the trypanosomatids sequenced to date. This expansion is reflected in the high …

Transmission of trypanosomatids to their mammalian hosts requires a complex series of
developmental transitions in their insect vectors, including stable attachment to an insect …

Methods for genetic manipulation of Trypanosoma cruzi, the etiologic agent of Chagas
disease, have been highly inefficient, and no endogenous tagging of genes has been …

In contrast to animal cells, the inositol 1, 4, 5-trisphosphate receptor of Trypanosoma cruzi
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …

Trypanosoma cruzi is the agent of Chagas disease, and the finding that this parasite
possesses a mitochondrial calcium uniporter (TcMCU) with characteristics similar to that of …

A decade of genome sequencing has transformed our understanding of how trypanosomatid
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …

Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the
most basal branch of the highly diverse parasitic trypanosomatids, which include human …

Trypanosomes regulate gene expression mainly by using posttranscriptional mechanisms.
Key factors responsible for carrying out this regulation are RNA-binding proteins, affecting …

Background During its life cycle, the human pathogen Trypanosoma cruzi must quickly
adapt to different environments, in which the variation in the gene expression of the …

Contractile vacuole complexes are critical components of cell volume regulation and have
been shown to have other functional roles in several free-living protists. However, very little …