Despite the successful development of new therapies for the treatment of type 2 diabetes,
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

The COVID-19 pandemic has been the primary global health issue since its outbreak in
December 2019. Patients with metabolic syndrome suffer from severe complications and a …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for
maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism …

Abstract Fibroblast growth factor 21 (FGF21) is a hepatokine that acts as a global starvation
signal to modulate fuel partitioning and metabolism and repress growth; however, the site of …

Personal data for 108 individuals were collected during a 9-month period, including whole
genome sequences; clinical tests, metabolomes, proteomes, and microbiomes at three time …

Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to
nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to …

Disturbances in protein folding and membrane compositions in the endoplasmic reticulum
(ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins …

Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs
show side effects and variable effectiveness. Thus, there is a tendency to use natural …