Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

Homeostasis of multicellular organisms is critically dependent on the correct interpretation of
the plethora of signals which cells are exposed to during their lifespan. Various soluble …

Protein phosphorylation provides molecular control of complex physiological events within
cells. In many cases, phosphorylation on specific amino acids directly controls the assembly …

To elucidate the hidden dynamics of extracellular-signal-regulated kinase (ERK) signalling
networks, we developed a simulation model of ERK signalling networks by constraining in …

Intracellular signaling pathways that involve protein tyrosine kinases (PTKs) are critical for
the control of most cellular processes. Dysfunctions in PTKs, or in the signaling pathways …

The Eph receptors comprise the largest group of receptor tyrosine kinases and are found in
a wide variety of cell types in developing and mature tissues. Their ligands are the ephrins, a …

Angiogenesis is required for normal embryonic vascular development and aberrant
angiogenesis contributes to several diseases, including cancer, diabetes and tissue …

Gab1 is a substrate of the receptor tyrosine kinase c-Met and involved in c-Met–specific
branching morphogenesis. It associates directly with c-Met via the c-Met–binding domain …

SH2/SH3 domain-containing adapter proteins, such as the Nck family, play a major role in
regulating tyrosine kinase signalling. They serve to recruit proline-rich effector molecules to …

Diet-induced obesity is the primary determinant of the current epidemic of diabetes. We have
explored the role of genetics in this phenomenon, using C57Bl/6 (B6), 129S6/SvEvTac …