Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Glycogen synthase kinase 3 (GSK-3) is a multifunctional serine/threonine kinase found in all
eukaryotes. The enzyme is a key regulator of numerous signalling pathways, including …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

The Wnt pathway controls numerous developmental processes via the β-catenin–TCF/LEF
transcription complex. Deregulation of the pathway results in the aberrant accumulation of β …

Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has
become an important strategy for treating neurodegenerative and psychiatric disorders. The …

Prediabetes and Alzheimer's disease both increase in prevalence with age. The former is a
risk factor for the latter, but a mechanistic linkage between them remains elusive. We show …

Glycogen synthase kinase-3 (GSK-3) is a critical, negative regulator of diverse signaling
pathways. Lithium is a direct inhibitor of GSK-3 and has been widely used to test the putative …

Abstract Glycogen synthase kinase 3 (GSK‐3) was initially described as a key enzyme
involved in glycogen metabolism, but is now known to regulate a diverse array of cell …