Endometrial cancer is one of the most common cancers of the female reproductive system.
Although surgery, radiotherapy, chemotherapy, and hormone therapy can significantly …

Menopause-related decline in estrogen levels is accompanied by a change in adipose
tissue distribution from a gynoid to an android and an increased prevalence of obesity in …

Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …

Background Chemotherapy is one of the most common treatment options for breast cancer
(BC) patients. However, about half of the BC patients are chemotherapeutic resistant …

Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose
tissue showing a pathological role in breast cancer development and malignancy via the …

Nicotinamide phosphoribosyltransferase (NAMPT) plays a central role in mammalian cell
metabolism by contributing to nicotinamide adenine dinucleotide biosynthesis. However …

Background Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major
enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway …

Enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in breast cancer and plays
an important role in maintaining the cell proliferative capacity. However, the mechanisms …

Sirtuin 1 is one of the regulators of cell growth and survival and its inhibition is suggested as
a suitable mechanism to overcome breast cancer development. In this study we explored the …

Breast cancer (BC) incidence and associated mortality have increased in tandem with the
growth in obesity among the females worldwide. An adipokine, visfatin, has been shown to …