[HTML][HTML] Design of experiments (DoE) applied to pharmaceutical and analytical quality by design (QbD)

IM Fukuda, CFF Pinto, CS Moreira… - Brazilian journal of …, 2018 - SciELO Brasil
According to Quality by Design (QbD) concept, quality should be built into product/method
during pharmaceutical/analytical development. Usually, there are many input factors that …

Recent advances in colon drug delivery systems

R Arévalo-Pérez, C Maderuelo, JM Lanao - Journal of Controlled Release, 2020 - Elsevier
As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

[HTML][HTML] Question-based review for pharmaceutical development: An enhanced quality approach

A Simões, F Veiga, C Vitorino - European Journal of Pharmaceutics and …, 2024 - Elsevier
Over the last years, the pharmaceutical industry has faced real challenges regarding quality
assurance. In this context, the establishment of more holistic approaches to the …

pH-responsive phthalate cashew gum nanoparticles for improving drugs delivery and anti-Trypanosoma cruzi efficacy

AC de Jesus Oliveira, EB Silva, TC de Oliveira… - International Journal of …, 2023 - Elsevier
Nanotechnology is a crucial technology in recent years has resulted in new and creative
applications of nanomedicine. Polymeric nanoparticles have increasing demands in …

Nanofibrous microspheres: a biomimetic platform for bone tissue regeneration

N Desai, S Pande, LK Vora… - ACS Applied Bio …, 2024 - ACS Publications
Bone, a fundamental constituent of the human body, is a vital scaffold for support, protection,
and locomotion, underscoring its pivotal role in maintaining skeletal integrity and overall …

Synthesis of Eudragit® L100-coated chitosan-based nanoparticles for oral enoxaparin delivery

YBG Patriota, IES Arruda, AC de Jesus Oliveira… - International Journal of …, 2021 - Elsevier
Enoxaparin is an effective biological molecule for prevention and treatment of coagulation
disorders. However, it is poorly absorbed in the gastrointestinal tract. In this study, we …

[HTML][HTML] Role of clove oil in solvent exchange-induced doxycycline hyclate-loaded Eudragit RS in situ forming gel

T Phaechamud, SM Thurein, T Chantadee - asian journal of …, 2018 - Elsevier
Solvent exchange induced in situ forming gel (ISG) is the promising drug delivery system for
periodontitis treatment owing to the prospect of maintaining an effective high drug level in …

Facilitating the use of the target product profile in academic research: a systematic review

A Ibnidris, N Liaskos, E Eldem, A Gunn… - Journal of Translational …, 2024 - Springer
Abstract Background The Target Product Profile (TPP) is a tool used in industry to guide
development strategies by addressing user needs and fostering effective communication …

Chemometric assisted natural DES based VA-DLLME-LC-MS/MS method for the quantitative determination of Garcinol in biofluids/tissues: A practical application to …

S Matta, MM Bhandi, K Javaji, S Misra… - … of Pharmaceutical and …, 2023 - Elsevier
Garcinol (GAR) is a polyisoprenylated benzophenone obtained from Garcinia indica used as
anti-oxidant and anti-inflammatory in traditional medicine and due to these activities, it …

Development of a curcumin-loaded polymeric microparticulate oral drug delivery system for colon targeting by quality-by-design approach

D Hales, LR Tefas, I Tomuță, C Moldovan, D Gulei… - Pharmaceutics, 2020 - mdpi.com
The purpose of this study was to apply the quality-by-design (QbD) approach for the
development of colon-targeted curcumin-loaded polymeric microparticles (Col-CUR-MPs) …