Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …

The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

As the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion
frequently undergoes morphological or positional changes when responding to various …

Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

The production of free radicals is inevitably associated with metabolism and other enzymatic
processes. Under physiological conditions, however, free radicals are effectively eliminated …

Ischaemic stroke is becoming the most common cerebral disease in aging populations, but
the underlying molecular mechanism of the disease has not yet been fully elucidated …

Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or
disability among the aging population globally. Oxidative stress has been closely linked with …