[HTML][HTML] Highlighting membrane protein structure and function: A celebration of the Protein Data Bank
Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …
and physical processes required for life. Many biological processes are carried out by …
[HTML][HTML] Towards next generation therapies for cystic fibrosis: folding, function and pharmacology of CFTR
The treatment of cystic fibrosis (CF) has been transformed by orally-bioavailable small
molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) …
molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) …
Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770
The past two decades have witnessed major breakthroughs in developing compounds that
target the chloride channel CFTR for the treatment of patients with cystic fibrosis. However …
target the chloride channel CFTR for the treatment of patients with cystic fibrosis. However …
Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond
The phosphorylation-activated anion channel cystic fibrosis transmembrane conductance
regulator (CFTR) is gated by an ATP hydrolysis cycle at its two cytosolic nucleotide-binding …
regulator (CFTR) is gated by an ATP hydrolysis cycle at its two cytosolic nucleotide-binding …
ABCG: a new fold of ABC exporters and a whole new bag of riddles!
ATP-binding cassette (ABC) superfamily comprises membrane transporters that power the
active transport of substrates across biological membranes. These proteins harness the …
active transport of substrates across biological membranes. These proteins harness the …
[HTML][HTML] Discovering the chloride pathway in the CFTR channel
B Farkas, H Tordai, R Padányi, A Tordai, J Gera… - Cellular and Molecular …, 2020 - Springer
Cystic fibrosis (CF), a lethal monogenic disease, is caused by pathogenic variants of the
CFTR chloride channel. The majority of CF mutations affect protein folding and stability …
CFTR chloride channel. The majority of CF mutations affect protein folding and stability …
[HTML][HTML] Activity of lumacaftor is not conserved in zebrafish Cftr bearing the major cystic fibrosis‐causing mutation
F508del‐cystic fibrosis transmembrane conductance regulator (CFTR) is the major mutant
responsible for cystic fibrosis (CF). ORKAMBI®, approved for patients bearing this mutant …
responsible for cystic fibrosis (CF). ORKAMBI®, approved for patients bearing this mutant …
[HTML][HTML] Challenges and opportunities in the development of novel antimicrobial therapeutics for cystic fibrosis
Chronic respiratory infection is the primary driver of mortality in individuals with cystic fibrosis
(CF). Existing drug screening models utilised in preclinical antimicrobial development are …
(CF). Existing drug screening models utilised in preclinical antimicrobial development are …
Optimization of CFTR gating through the evolution of its extracellular loops
CFTR chloride channel mutations cause the lethal and incurable disease cystic fibrosis (CF).
CFTR is activated by phosphorylation, and phosphorylated channels exhibit “bursting” …
CFTR is activated by phosphorylation, and phosphorylated channels exhibit “bursting” …
CFTR regulation of aquaporin-mediated water transport
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel
responsible for the direct transport of bicarbonate and chloride. CFTR-dependent ionic …
responsible for the direct transport of bicarbonate and chloride. CFTR-dependent ionic …