Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By
linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF …

Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of
action remains a mystery. It is well known for regulating mitochondrial function and coupling …

In nature, the folding and conformation of proteins can control the cell or organelle
membrane permeability and regulate the life activities. Here we report the first example of …

Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout
evolution and present in all studied organisms. In mammals, it shows a high co-localization …

Inorganic polyphosphate (polyP) is a linear polymer composed of up to a few hundred
orthophosphates linked together by high-energy phosphoanhydride bonds, identical with …

Inorganic polyphosphate (polyP) is an ancient, ubiquitous, and well-conserved polymer
which is present in all the studied organisms. It is formed by individual subunits of …

Mitochondrial free calcium is critically linked to the regulation of cellular metabolism. Free
ionic calcium concentration within these organelles is determined by the interplay between …

Acetaminophen (APAP) overdose is the most frequent cause of liver injury and acute liver
failure in many western countries. The mechanism of APAP-induced hepatocyte necrosis …

Advanced age is the greatest risk factor for aging-related brain disorders including
Alzheimer's disease (AD). However, the detailed mechanisms that mechanistically link aging …