In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Enveloped viruses encompass some of the most common human pathogens causing
infections of different severity, ranging from no or very few symptoms to lethal disease as …

The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs
in response to infection with DNA viruses and to presence of host DNA in the cytosol …

Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral
infection and are crucial for control of viral replication and dissemination, especially at …

Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in
industrialized countries. Type I interferon (IFN) is important for control of herpes simplex …

Herpes simplex virus (HSV) naturally infects skin and mucosal surfaces, causing lifelong
recurrent disease worldwide, with no cure or vaccine. Biomimetic human tissue and organ …

Neutrophils are essential for innate immunity and inflammation and many neutrophil
functions are β2 integrin-dependent. Integrins can extend (E+) and acquire a high-affinity …