Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

We are now near the top of the mitochondrial pathway of apoptosis, at the point before the
mitochondrial outer membrane permeabilizes to release proteins such as cytochrome c into …

Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …

In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal …

Mitochondria are highly plastic and dynamic organelles that have graded responses to the
changing cellular, environmental, and developmental cues. Mitochondria undergo constant …

INTRODUCTION There has been an explosion of interest in the role of cell death pathways
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …

Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of
apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial …

Mitochondria are complex organelles that play a central role in energy metabolism, control
of stress responses and are a hub for biosynthetic processes. Beyond its well-established …