Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities
The host immune system plays an important role in chronic hepatitis B (CHB), both in viral
clearance and hepatocellular damage. Advances in our understanding of the natural history …
clearance and hepatocellular damage. Advances in our understanding of the natural history …
[PDF][PDF] Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B
Hepatitis B virus (HBV) infection represents a significant public health burden worldwide.
Although current therapeutics manage to control the disease progression, lifelong treatment …
Although current therapeutics manage to control the disease progression, lifelong treatment …
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
[HTML][HTML] HBsAg loss with peg-interferon alfa-2a in hepatitis B patients with partial response to nucleos (t) ide analog: new switch study
P Hu, J Shang, W Zhang, G Gong, Y Li… - Journal of clinical and …, 2018 - ncbi.nlm.nih.gov
Abstract Background and Aims: Hepatitis B surface antigen (HBsAg) loss is seldom
achieved with nucleos (t) ide analog (NA) therapy in chronic hepatitis B patients but may be …
achieved with nucleos (t) ide analog (NA) therapy in chronic hepatitis B patients but may be …
Prospects for the global elimination of hepatitis B
Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics
Persistent hepatitis B virus (HBV) infection relies on the stable maintenance and proper
functioning of a nuclear episomal form of the viral genome called covalently closed circular …
functioning of a nuclear episomal form of the viral genome called covalently closed circular …
[HTML][HTML] Hepatitis B virus and its sexually transmitted infection-an update
T Inoue, Y Tanaka - Microbial cell, 2016 - ncbi.nlm.nih.gov
Epidemiology: incidence and prevalence: About 5% of the world's population has chronic
hepatitis B virus (HBV) infection, and nearly 25% of carriers develop chronic hepatitis …
hepatitis B virus (HBV) infection, and nearly 25% of carriers develop chronic hepatitis …
[HTML][HTML] Immunotherapy for chronic hepatitis B virus infection
A Bertoletti, N Le Bert - Gut and liver, 2018 - ncbi.nlm.nih.gov
While new therapies for chronic hepatitis C virus infection have delivered remarkable cure
rates, curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal …
rates, curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal …
The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation
Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription
template, which plays a pivotal role in viral infection and persistence. Upon infection, the non …
template, which plays a pivotal role in viral infection and persistence. Upon infection, the non …
A potent human neutralizing antibody Fc-dependently reduces established HBV infections
Hepatitis B virus (HBV) infection is a major global health problem. Currently-available
therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D …
therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D …