Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Adult neurogenesis is limited to specific brain regions in the mammalian brain, such as the
hippocampal dentate gyrus and the subventricular zone/olfactory bulb system. Alterations in …

Behavioural, cellular and molecular studies have revealed significant effects of enriched
environments on rodents and other species, and provided new insights into mechanisms of …

Research in humans and animals has shown that exercise improves mood and cognition.
Physical activity also causes a robust increase in neurogenesis in the dentate gyrus of the …

The generation and cell death of newly generated cells have critical roles in brain
development and maintenance in the embryonic and adult brain. Alterations in these …

Environmental enrichment (EE) increases levels of novelty and complexity, inducing
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …

Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …

Huntington's disease (HD) is one of the few neurodegenerative diseases with a known
genetic cause, knowledge that has enabled the creation of animal models using genetic …

Environmental stimulation throughout development adjusts the neurobehavioral systems
involved in learning, memory and defensive responses. Environment-mediated phenotypic …

The demonstration that progenitor cells in regions of the adult mammalian brain such as the
dentate gyrus of the hippocampus can undergo mitosis and generate new cells that …