MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation

JD Tournier, R Smith, D Raffelt, R Tabbara… - Neuroimage, 2019 - Elsevier
MRtrix3 is an open-source, cross-platform software package for medical image processing,
analysis and visualisation, with a particular emphasis on the investigation of the brain using …

[HTML][HTML] Fixel-based analysis of diffusion MRI: methods, applications, challenges and opportunities

T Dhollander, A Clemente, M Singh, F Boonstra… - Neuroimage, 2021 - Elsevier
Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-
vivo data sensitive to microstructural features of white matter, up to 3 orders of magnitude …

[HTML][HTML] Investigating white matter fibre density and morphology using fixel-based analysis

DA Raffelt, JD Tournier, RE Smith, DN Vaughan… - Neuroimage, 2017 - Elsevier
Voxel-based analysis of diffusion MRI data is increasingly popular. However, most white
matter voxels contain contributions from multiple fibre populations (often referred to as …

[HTML][HTML] What's new and what's next in diffusion MRI preprocessing

CMW Tax, M Bastiani, J Veraart, E Garyfallidis… - NeuroImage, 2022 - Elsevier
Diffusion MRI (dMRI) provides invaluable information for the study of tissue microstructure
and brain connectivity, but suffers from a range of imaging artifacts that greatly challenge the …

Fibre-specific white matter reductions in Alzheimer's disease and mild cognitive impairment

R Mito, D Raffelt, T Dhollander, DN Vaughan… - Brain, 2018 - academic.oup.com
Alzheimer's disease is increasingly considered a large-scale network disconnection
syndrome, associated with progressive aggregation of pathological proteins, cortical …

Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging

B Jeurissen, A Leemans, JD Tournier… - Human brain …, 2013 - Wiley Online Library
It has long been recognized that the diffusion tensor model is inappropriate to characterize
complex fiber architecture, causing tensor‐derived measures such as the primary …

[HTML][HTML] Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres

DA Raffelt, RE Smith, GR Ridgway, JD Tournier… - Neuroimage, 2015 - Elsevier
In brain regions containing crossing fibre bundles, voxel-average diffusion MRI measures
such as fractional anisotropy (FA) are difficult to interpret, and lack within-voxel single fibre …

Apparent fibre density: a novel measure for the analysis of diffusion-weighted magnetic resonance images

D Raffelt, JD Tournier, S Rose, GR Ridgway… - Neuroimage, 2012 - Elsevier
This article proposes a new measure called Apparent Fibre Density (AFD) for the analysis of
high angular resolution diffusion-weighted images using higher-order information provided …

[HTML][HTML] Combined tract segmentation and orientation mapping for bundle-specific tractography

J Wasserthal, PF Neher, D Hirjak, KH Maier-Hein - Medical image analysis, 2019 - Elsevier
While the major white matter tracts are of great interest to numerous studies in neuroscience
and medicine, their manual dissection in larger cohorts from diffusion MRI tractograms is …

Sequence of clinical and neurodegeneration events in Parkinson's disease progression

NP Oxtoby, LA Leyland, LM Aksman, GEC Thomas… - Brain, 2021 - academic.oup.com
Dementia is one of the most debilitating aspects of Parkinson's disease. There are no
validated biomarkers that can track Parkinson's disease progression, nor accurately identify …