This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Quantitative computed tomography (QCT) was introduced in the mid 1970s. The technique
is most commonly applied to 2D slices in the lumbar spine to measure trabecular bone …

Background: Despite the high prevalence of hypovitaminosis D in children and adolescents
worldwide, the impact of vitamin D deficiency on skeletal health is unclear. Methods: One …

Context: There has been a resurgence of vitamin D deficiency among infants, toddlers, and
adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D …

Bone densitometric data are often difficult to interpret in children and adolescents because
of large inter-and intraindividual variations in bone size. Here, we propose a functional …

A longitudinal sample of 20 subjects, measured an average of 34 to 35 times each at
approximately 6-month intervals from near birth through late adolescence, was used to …

Muscle and bone are anatomically and functionally closely connected. The traditional
concept that skeletal muscles serve to load bone and transform skeletal segments into a …

As muscles become larger and stronger during growth and in response to increased
loading, bones should adapt by adding mass, size, and strength. In this unilateral model, we …

Cyclical intravenous bisphosphonate therapy is widely used to treat children with
osteogenesis imperfecta (OI), but little is known about long‐term treatment outcomes. We …