Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment
YH Zhu, JH Zheng, QY Jia, ZH Duan, HF Yao, J Yang… - Cellular Oncology, 2023 - Springer
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
characterized by poor treatment response and low survival time. The current clinical …
characterized by poor treatment response and low survival time. The current clinical …
Modeling pancreatic cancer in mice for experimental therapeutics
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is associated with highly immunosuppressive
tumor microenvironment (TME) that can limit the efficacy of dendritic cell (DC) vaccine …
tumor microenvironment (TME) that can limit the efficacy of dendritic cell (DC) vaccine …
The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1/NF …
Q Li, J He, S Li, C Tian, J Yang, H Yuan, Y Lu… - Clinical …, 2023 - Elsevier
Cold tumor immune microenvironment (TIME) of pancreatic cancer (PC) with minimal
dendritic cell (DC) and T cell infiltration can result in insufficient immunotherapy and …
dendritic cell (DC) and T cell infiltration can result in insufficient immunotherapy and …
[HTML][HTML] Research progress of neoantigen-based dendritic cell vaccines in pancreatic cancer
X Zhang, Z Xu, X Dai, X Zhang, X Wang - Frontiers in Immunology, 2023 - frontiersin.org
The mutation of the crucial genes such as tumor suppressors or oncogenes plays an
important role in the initiation and development of tumors. The non-synonymous mutations …
important role in the initiation and development of tumors. The non-synonymous mutations …
Detection of immunotherapeutic response in a transgenic mouse model of pancreatic ductal adenocarcinoma using multiparametric MRI radiomics: a preliminary …
Rationale and Objectives To develop classification and regression models interpreting
tumor characteristics obtained from structural (T1w and T2w) magnetic resonance imaging …
tumor characteristics obtained from structural (T1w and T2w) magnetic resonance imaging …
[HTML][HTML] Effect of route of administration on the efficacy of dendritic cell vaccine in PDAC mice
It is unknown whether the route of administration impacts dendritic cell (DC)-based
immunotherapy for pancreatic ductal adenocarcinoma (PDAC). We compared the effect of …
immunotherapy for pancreatic ductal adenocarcinoma (PDAC). We compared the effect of …
[PDF][PDF] Dendritic cell vaccination combined with irreversible electroporation for treating pancreatic cancer—a narrative review
Key Content and Findings: IRE ablation destructs tumor structure while preserving
extracellular matrix and blood vessels facilitating local inflammation. The studies …
extracellular matrix and blood vessels facilitating local inflammation. The studies …
Prophylactic Dendritic Cell Vaccination in Experimental Breast Cancer Controls Immunity and Hepatic Metastases
JF Vieira, AP Peixoto, EFC Murta… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: Liver metastases are among the principal mortality causes in cancer
patients. Dendritic cell immunotherapies have shown promising results in some tumors by …
patients. Dendritic cell immunotherapies have shown promising results in some tumors by …
CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport
C Tian, H Yuan, Y Lu, H He, Q Li, S Li, J Yang… - …, 2023 - Taylor & Francis
Pancreatic cancer (PC) is featured with low survival rate and poor outcomes. Herein, we
found that the expression of caspase-recruitment domain-containing protein 9 (CARD9) …
found that the expression of caspase-recruitment domain-containing protein 9 (CARD9) …