Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year
survival rate is less than 10%, even in developed countries such as the USA. The genomic …

Every cell in the body requires oxygen for its functioning, in virtually every animal, and a
tightly regulated system that balances oxygen supply and demand is therefore fundamental …

Image-guided nanotheranostics have the potential to represent a new paradigm in the
treatment of cancer. Recent developments in modern imaging and nanoparticle design offer …

Lysosomal biogenesis plays a vital role in cell fate. Under certain conditions, excessive
lysosomal biogenesis leads to susceptibility for lysosomal membrane permeabilization …

Background: Nano drug delivery system (NDDS) can significantly improve the delivery and
efficacy of drugs against pancreatic cancer (PC) in many ways. The purpose of this study is …

Echinomycin is a natural compound discovered and isolated from bacteria, introduced as a
promising antibiotic and anticancer therapy. However, it failed clinically due to improper …

Hepatocellular carcinoma (HCC) patients usually fail to be treated because of drug
resistance, including sorafenib. In this study, the effects of CASK in HCC were investigated …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most recalcitrant cancers due to its
late diagnosis, poor therapeutic response, and highly heterogeneous microenvironment …

Purpose To develop optoacoustic, spectrally distinct, actively targeted gold nanoparticle–
based near-infrared probes (trastuzumab [TRA], TRA-Aurelia-1, and TRA-Aurelia-2) that can …

Retinal hypoxia stands as a pivotal yet often underappreciated factor in the etiology and
progression of many retinal disorders such as glaucoma, hypertensive retinopathy, diabetic …