The mesocorticolimbic pathway is canonically known as the" reward pathway." Embedded
within the center of this circuit is the striatum, a massive and complex network hub that …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

Postoperative cognitive dysfunction (POCD) is a common postoperative complication
involving the central nervous system, but the underlying mechanism is not well understood …

Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

Powerful associations that link drugs of abuse with cues in the drug-paired environment
often serve as prepotent relapse triggers. Drug-associated contexts and cues activate …

A growing body of evidence from the past 15 years implicates epigenetic mechanisms in the
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …

Rates of individuals struggling with psychostimulant use disorder (PSUD), defined as
chronic use of psychostimulants despite negative consequences, are growing rapidly over …

Chronic stress can produce reward system deficits (ie, anhedonia) and other common
symptoms associated with depressive disorders, as well as neural circuit hypofunction in the …

Addiction has been conceptualized as a disease of learning and memory. Learned
associations between environmental cues and unconditioned rewards induced by drug …