The resolution of inflammation is an active and dynamic process, mediated in large part by
the innate immune system. Resolution represents not only an increase in anti‐inflammatory …

Background. A nascent explanatory theory regarding the pathophysiology of major
depressive disorder posits that alterations in metabolic networks (eg, insulin and …

Tissue damage resulting from chemical, mechanical, and biological injury, or from
interrupted blood flow and reperfusion, is often life threatening. The subsequent tissue …

Lipid mediators can trigger physiological responses by activating nuclear hormone
receptors, such as the peroxisome proliferator‐activated receptors (PPARs). PPARs, in turn …

Significance: Endothelial cells lining the lumen of blood vessels play an important role in the
regulation of cardiovascular functions through releasing both vasoconstricting and …

BACKGROUND: Accumulative evidence suggested that oxidative stress and inflammation
were involved in the pathogenesis of atrial fibrillation (AF). Thiazolidinediones (TZDs) …

Mangiferin (MF), a xanthonoid from Mangifera indica, has been proved to have antisecretory
and antioxidant gastroprotective effects against different gastric ulcer models; however, its …

Objective (s): The aim of current study was to evaluate improving effects of pioglitazone as
an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), on brain-derived …

BACKGROUND: Reactive oxygen species (ROSs) play a crucial role in the pathogenesis of
airway inflammation. Peroxisome proliferator activated receptor (PPAR)-γ is also involved in …

Status epilepticus (SE) can cause severe neuronal loss and oxidative damage. As
peroxisome proliferator-activated receptor gamma (PPARγ) agonists possess antioxidative …