The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of
infectious disease treatment. To overcome this problem, novel strategies are being explored …

Novel antibacterial therapies are urgently required to tackle the increasing number of
multidrug‐resistant pathogens. Identification of new antimicrobial targets is critical to avoid …

Community-associated and hospital-acquired infections caused by bacteria continue to yield
major global challenges to human health. Bacterial contamination on abiotic surfaces is …

Combining pentamidine with Gram-positive-targeting antibiotics has been proven to be a
promising strategy for treating infections from Gram-negative bacteria (GNB). However …

Inhibition of multiple cancer-related pathways has made niclosamide a promising candidate
for the treatment of various cancers. However, its clinical application has been significantly …

Ethnopharmacology relevance Cananga oil (CO) is derived from the flowers of the
traditional medicinal plant, the ylang-ylang tree. As a traditional antidepressant, CO is …

Small molecule can be utilized to restore the effectiveness of existing major classes of
antibiotics against antibiotic‐resistant bacteria. In this study, it is demonstrated that celastrol …

Frequently, subcellular-targeted drugs tend to accumulate in lysosomes after cellular
absorption, a process termed the lysosomal trap. This accumulation often interferes with the …

The journey of drug discovery (DD) has evolved from ancient practices to modern
technology-driven approaches, with Artificial Intelligence (AI) emerging as a pivotal force in …

Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria,
potentially acting as antagonists by inducing cell dormancy and promoting cell survival …