Diagnosis of neonatal sepsis: the past, present and future

IH Celik, M Hanna, FE Canpolat, M Pammi - Pediatric research, 2022 - nature.com
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

Necrotizing enterocolitis: new insights into pathogenesis and mechanisms

DF Niño, CP Sodhi, DJ Hackam - Nature reviews Gastroenterology & …, 2016 - nature.com
Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …

Culture-negative early-onset neonatal sepsis—at the crossroad between efficient sepsis care and antimicrobial stewardship

C Klingenberg, RF Kornelisse, G Buonocore… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …

Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis

JY Ting, A Synnes, A Roberts, A Deshpandey… - JAMA …, 2016 - jamanetwork.com
Importance Excessive antibiotic use has been associated with altered bacterial colonization
and may result in antibiotic resistance, fungemia, necrotizing enterocolitis (NEC), and …

Surgical necrotizing enterocolitis

JR Robinson, EJ Rellinger, LD Hatch… - Seminars in …, 2017 - Elsevier
Although currently available data are variable, it appears that the incidence of surgical
necrotizing enterocolitis (NEC) has not decreased significantly over the past decade …

New medical and surgical insights into neonatal necrotizing enterocolitis: a review

BL Frost, BP Modi, T Jaksic, MS Caplan - JAMA pediatrics, 2017 - jamanetwork.com
Importance Necrotizing enterocolitis (NEC) has long remained a significant cause of
morbidity and mortality in neonatal intensive care units. While the mainstay of treatment for …

Early-onset sepsis and antibiotic exposure in term infants: a nationwide population-based study in Norway

JW Fjalstad, HJ Stensvold, H Bergseng… - The Pediatric …, 2016 - journals.lww.com
Background: Sepsis is a leading cause of neonatal morbidity and mortality. Clinical
suspicion may lead to overuse of antibiotics. The objective of this study was to assess the …

Neonatal bacterial sepsis

T Strunk, EJ Molloy, A Mishra, ZA Bhutta - The Lancet, 2024 - thelancet.com
Neonatal sepsis remains one of the key challenges of neonatal medicine, and together with
preterm birth, causes almost 50% of all deaths globally for children younger than 5 years …

Current research on the epidemiology, pathogenesis, and management of necrotizing enterocolitis

S Eaton, CM Rees, NJ Hall - Neonatology, 2017 - karger.com
Despite decades of research on necrotizing enterocolitis, we still do not fully understand the
pathogenesis of the disease, or how to prevent or how to treat it. However, as a result of …

Relevance of biomarkers currently in use or research for practical diagnosis approach of neonatal early-onset sepsis

MA Hincu, GI Zonda, GD Stanciu, D Nemescu… - Children, 2020 - mdpi.com
Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first
72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up …