During the past decade, in vivo administration of viral gene transfer vectors for treatment of
numerous human diseases has been brought from bench to bedside in the form of clinical …

T lymphocytes play a crucial role in the host's immune response to cancer. Although there is
ample evidence for the presence of tumor-associated antigens on a variety of tumors, they …

Augmenting cancer treatment by protein and gene delivery continues to gain momentum
based on success in animal models. The primary hurdle of fully exploiting the arsenal of …

A cancer treatment is described in which im injection of plasmid DNA (pDNA) encoding
murine interferon α (mIFN-α) leads to potent antitumor effects on primary and metastatic …

Treatment of a human breast cancer cell line (MDA-MB-435) in nude mice with a
recombinant adenovirus containing the human interferon (IFN) consensus gene, IFN-con1 …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
27371088&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Gene therapy involves the transfer of genetic information to a target cell to facilitate the
production of therapeutic proteins and is now a realistic prospect as a cancer treatment …

Type I interferons (IFNs), pleiotropic cytokines with antiviral, antiproliferative, apoptotic, and
immunoregulatory functions, are efficacious in the treatment of malignancies, viral infections …

Telomerase reactivation is a critical step for tumorigenesis, allowing cancer cells to
proliferate indefinitely. Taking advantage of this property, we generated an adenovirus …

Viral vectors are promising gene carriers for cancer therapy. However, virus-mediated gene
therapies have demonstrated insufficient therapeutic efficacy in clinical trials due to rapid …