Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …
Tau-targeting therapies for Alzheimer disease
EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice
Y Zhao, Q Zheng, Y Hong, Y Gao, J Hu, M Lang… - Nature …, 2023 - nature.com
Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …
Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein
H Jung, SY Lee, S Lim, HR Choi, Y Choi, M Kim… - Nature Medicine, 2022 - nature.com
Clearing amyloid-β (Aβ) through immunotherapy is one of the most promising therapeutic
approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against …
approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against …
The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function
The innate immune system is strongly implicated in the pathogenesis of Alzheimer's disease
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However …
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However …
LC3-associated endocytosis facilitates β-amyloid clearance and mitigates neurodegeneration in murine Alzheimer's disease
BL Heckmann, BJW Teubner, B Tummers… - Cell, 2019 - cell.com
The expression of some proteins in the autophagy pathway declines with age, which may
impact neurodegeneration in diseases, including Alzheimer's Disease. We have identified a …
impact neurodegeneration in diseases, including Alzheimer's Disease. We have identified a …
Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease
Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease
C Villegas-Llerena, A Phillips… - Current opinion in …, 2016 - Elsevier
Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), and microglia,
the brain's resident phagocyte, are pivotal for the immune response observed in AD …
the brain's resident phagocyte, are pivotal for the immune response observed in AD …
Immune system responses in Parkinson's disease: early and dynamic
MG Tansey, M Romero‐Ramos - European Journal of …, 2019 - Wiley Online Library
The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and
death of dopamine‐producing neurons in the ventral midbrain, the widespread …
death of dopamine‐producing neurons in the ventral midbrain, the widespread …