Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Tau-targeting therapies for Alzheimer disease: current status and future directions

EE Congdon, C Ji, AM Tetlow, Y Jiang… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice

Y Zhao, Q Zheng, Y Hong, Y Gao, J Hu, M Lang… - Nature …, 2023 - nature.com
Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …

Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein

H Jung, SY Lee, S Lim, HR Choi, Y Choi, M Kim… - Nature Medicine, 2022 - nature.com
Clearing amyloid-β (Aβ) through immunotherapy is one of the most promising therapeutic
approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against …

The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function

SE Marsh, EM Abud, A Lakatos… - Proceedings of the …, 2016 - National Acad Sciences
The innate immune system is strongly implicated in the pathogenesis of Alzheimer's disease
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However …

LC3-associated endocytosis facilitates β-amyloid clearance and mitigates neurodegeneration in murine Alzheimer's disease

BL Heckmann, BJW Teubner, B Tummers… - Cell, 2019 - cell.com
The expression of some proteins in the autophagy pathway declines with age, which may
impact neurodegeneration in diseases, including Alzheimer's Disease. We have identified a …

Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease

YD Li, YJ Luo, L Xie, DS Tart, RN Sheehy, L Zhang… - Cell stem cell, 2023 - cell.com
Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

C Villegas-Llerena, A Phillips… - Current opinion in …, 2016 - Elsevier
Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), and microglia,
the brain's resident phagocyte, are pivotal for the immune response observed in AD …

Immune system responses in Parkinson's disease: early and dynamic

MG Tansey, M Romero‐Ramos - European Journal of …, 2019 - Wiley Online Library
The neuropathological hallmarks of Parkinson's disease (PD) are the degeneration and
death of dopamine‐producing neurons in the ventral midbrain, the widespread …