Clinical progress and advanced research of red blood cells based drug delivery system

Y Li, F Raza, Y Liu, Y Wei, R Rong, M Zheng, W Yuan… - Biomaterials, 2021 - Elsevier
Red blood cells (RBCs) are biocompatible carriers that can be employed to deliver different
bioactive substances. In the past few decades, many strategies have been developed to …

Ataxia

U Akbar, T Ashizawa - Neurologic clinics, 2015 - neurologic.theclinics.com
Complex circuitry connecting the basal ganglia, cerebellum, and cerebral cortex is involved
in producing coordinated movements of the eyes and limbs. Malfunction of any part of this …

Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences

X Song, F Ma, K Herrup - Journal of Neuroscience, 2019 - Soc Neuroscience
ATM (ataxia-telangiectasia mutated) is a PI3K-like kinase best known for its role in the DNA
damage response (DDR), especially after double-strand breaks. Mutations in the ATM gene …

NAD+ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy

B Yang, X Dan, Y Hou, JH Lee, N Wechter… - Aging cell, 2021 - Wiley Online Library
Senescence phenotypes and mitochondrial dysfunction are implicated in aging and in
premature aging diseases, including ataxia telangiectasia (A‐T). Loss of mitochondrial …

Drug-loaded erythrocytes: on the road toward marketing approval

V Bourgeaux, JM Lanao, BE Bax… - … design, development and …, 2016 - Taylor & Francis
Erythrocyte drug encapsulation is one of the most promising therapeutic alternative
approaches for the administration of toxic or rapidly cleared drugs. Drug-loaded erythrocytes …

Ataxia-telangiectasia: future prospects

MW Chaudhary, RS Al-Baradie - The application of clinical …, 2014 - Taylor & Francis
Ataxia-telangiectasia (AT) is an autosomal recessive multi-system disorder caused by
mutation in the ataxia-telangiectasia mutated gene (ATM). ATM is a large serine/threonine …

Inflammation, a significant player of Ataxia–Telangiectasia pathogenesis?

M Zaki-Dizaji, SM Akrami, G Azizi, H Abolhassani… - Inflammation …, 2018 - Springer
Abstract Introduction Ataxia–Telangiectasia (AT) syndrome is an autosomal recessive
neurodegenerative disorder characterized by cerebellar ataxia, oculocutaneous …

Leishmania infantum Induces Mild Unfolded Protein Response in Infected Macrophages

L Galluzzi, A Diotallevi, M De Santi, M Ceccarelli… - PloS one, 2016 - journals.plos.org
The Leishmaniases are a group of parasitic diseases caused by protozoa of the Leishmania
genus affecting both humans and other vertebrates. Leishmania is an intracellular pathogen …

Ataxia telangiectasia

A Nissenkorn, B Ben-Zeev - Handbook of clinical neurology, 2015 - Elsevier
Ataxia telangiectasia (AT) is an autosomal recessive multisystem genetic disorder caused by
a mutation in the ATM gene encoding for the ATM protein. AT systemic manifestations …

Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2‐mediated antioxidant response

S Biagiotti, M Menotta, S Orazi, C Spapperi… - The FEBS …, 2016 - Wiley Online Library
Ataxia telangiectasia (A‐T) is a rare incurable neurodegenerative disease caused by
biallelic mutations in the gene for ataxia‐telangiectasia mutated (ATM). The lack of a …