Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities
MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …
characterized by episodic and often progressive mood fluctuations with manic and …
Inflammatory signaling mechanisms in bipolar disorder
GH Jones, CM Vecera, OF Pinjari… - Journal of Biomedical …, 2021 - Springer
Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …
individual and societal burden. While not all patients display overt markers of elevated …
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders
Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …
evidence that peripheral systems are also involved in mood, stress vulnerability vs …
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites
Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in
bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the …
bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the …
The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis
M Morrens, C Overloop, V Coppens, E Loots… - Molecular …, 2022 - nature.com
Background In psychotic and mood disorders, immune alterations are hypothesized to
underlie cognitive symptoms, as they have been associated with elevated blood levels of …
underlie cognitive symptoms, as they have been associated with elevated blood levels of …
Association between diffusion tensor imaging, inflammation and immunological alterations in unipolar and bipolar depression: a review
Abstract Major Depressive Disorder (MDD) and Bipolar Disorder Depression (BDD) are
common psychiatric illnesses characterized by structural and functional brain alterations and …
common psychiatric illnesses characterized by structural and functional brain alterations and …
Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that
alternate between mania and hypomania or between depression and mixed states, often …
alternate between mania and hypomania or between depression and mixed states, often …
[HTML][HTML] The tryptophan catabolite or kynurenine pathway in major depressive and bipolar disorder: A systematic review and meta-analysis
AF Almulla, Y Thipakorn, A Vasupanrajit… - Brain, behavior, & …, 2022 - Elsevier
Background There is now evidence that affective disorders including major depressive
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …
Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression
Bipolar (BD) and major depression (MDD) disorders are severe mental illnesses
characterised by altered levels of immune/inflammatory markers and disrupted white matter …
characterised by altered levels of immune/inflammatory markers and disrupted white matter …
The tryptophan catabolite or kynurenine pathway in a major depressive episode with melancholia, psychotic features and suicidal behaviors: a systematic review and …
AF Almulla, Y Thipakorn, A Vasupanrajit… - Cells, 2022 - mdpi.com
Major depressive disorder (MDD) and bipolar disorder (BD) with melancholia and psychotic
features and suicidal behaviors are accompanied by activated immune-inflammatory and …
features and suicidal behaviors are accompanied by activated immune-inflammatory and …