Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …

Excessive alcohol consumption is involved in 1/10 of deaths of US working-age adults and
costs the country around $250,000,000 yearly. While Alcohol Use Disorder (AUD) pathology …

Alcohol use disorder (AUD) is a public health issue that affects millions of people worldwide
leading to physical, mental and socio-economic consequences. While current treatments for …

The dose-dependent effects of alcohol, where the initial euphoric and stimulant effects
initiated by the exposure to low ethanol levels can quickly lead to a deadly consequence are …

Background Previous research has demonstrated the utility of subanesthetic doses of
ketamine in decreasing binge (Drinking-in-the-Dark, or DID) 20% alcohol intake in female …

Depression usually emerges during adolescence, is significantly more frequent in women,
and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies …

Ethanol or ethyl alcohol is an age-old substance with abuse potential that can lead to a
myriad of organ damage as well as behavioral and neurotoxicological consequences …

Objectives Pilot study validating the animal model of depression–the bilateral olfactory
bulbectomy in rats–by two nuclear magnetic resonance methods, indirectly detecting the …

Background α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors
are ionotropic glutamate receptors that have been investigated for their role in modulating …

Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces
quick and effective antidepressant results in depressed juvenile and adult individuals. The …