The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …

There has been a drive to develop new cell based therapies to treat corneal blindness, one
of the most common causes of blindness worldwide. Mechanical and physical cues are …

In diabetic patients, cardiomyopathy is an important cause of heart failure, but its
pathophysiology has not been completely understood thus far. Myocardial hypertrophy and …

Many diseases are related to changes in cell mechanics. Atomic Force Microscopy (AFM) is
one of the most suitable techniques allowing the investigation of both topography and …

The transient period of regeneration potential in the postnatal heart suggests molecular
changes with maturation influence the cardiac response to damage. We have previously …

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized
by progressive replacement of cardiomyocytes by fibrofatty tissue, ventricular dilatation …

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome
responsible for high mortality and morbidity rates. It has an ever growing social and …

Fibroblasts are a major cell population that perform critical functions in the wound healing
process. In response to injury, they proliferate and migrate into the wound space, engaging …

Cardiomyocytes generate force for the contraction of the heart to pump blood into the lungs
and body. At the same time, they are exquisitely tuned to the mechanical environment and …

Cardiovascular/heart tissue and cells are subjected to dynamic forces from very early
development, without pause, for the entire life of the animal or person and are characterized …