Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics
JJ Rennick, APR Johnston, RG Parton - Nature nanotechnology, 2021 - nature.com
Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
HT McMahon, E Boucrot - Nature reviews Molecular cell biology, 2011 - nature.com
Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …
Analysis of the chronic wound microbiota of 2,963 patients by 16S rDNA pyrosequencing
The extent to which microorganisms impair wound healing is an ongoing controversy in the
management of chronic wounds. Because the high diversity and extreme variability of the …
management of chronic wounds. Because the high diversity and extreme variability of the …
Dynamin, a membrane-remodelling GTPase
SM Ferguson, P De Camilli - Nature reviews Molecular cell biology, 2012 - nature.com
Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …
Molecular structure, function, and dynamics of clathrin-mediated membrane traffic
T Kirchhausen, D Owen… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …
Mechanisms of endocytosis
GJ Doherty, HT McMahon - Annual review of biochemistry, 2009 - annualreviews.org
Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …
thereby regulating how cells interact with their environments. Here, we review what is known …
Endocytosis of viruses and bacteria
P Cossart, A Helenius - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …
organism as protected sites for replication. To reach the relevant intracellular compartments …
Nanoparticle entry into cells; the cell biology weak link
G Griffiths, J Gruenberg, M Marsh, J Wohlmann… - Advanced Drug Delivery …, 2022 - Elsevier
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation
Interkingdom signaling is established in the gastrointestinal tract in that human hormones
trigger responses in bacteria; here, we show that the corollary is true, that a specific bacterial …
trigger responses in bacteria; here, we show that the corollary is true, that a specific bacterial …
[HTML][HTML] Peroxisomes are signaling platforms for antiviral innate immunity
Peroxisomes have long been established to play a central role in regulating various
metabolic activities in mammalian cells. These organelles act in concert with mitochondria to …
metabolic activities in mammalian cells. These organelles act in concert with mitochondria to …