Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

V Kumar, X Xin, J Ma, C Tan, N Osna… - Advanced drug delivery …, 2021 - Elsevier
Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

Metabolic spectrum of liver failure in type 2 diabetes and obesity: from NAFLD to NASH to HCC

H Kim, DS Lee, TH An, HJ Park, WK Kim… - International journal of …, 2021 - mdpi.com
Liver disease is the spectrum of liver damage ranging from simple steatosis called as
nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). Clinically …

Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis‐related NLRP3 pathway

S Song, R Guo, A Mehmood, L Zhang… - CNS neuroscience & …, 2022 - Wiley Online Library
Aims Multiple sclerosis (MS) still maintains increasing prevalence and poor prognosis, while
glucagon‐like peptide‐1 receptor (GLP‐1R) agonists show excellent neuroprotective …

Alleviation of depression by glucagon-like peptide 1 through the regulation of neuroinflammation, neurotransmitters, neurogenesis, and synaptic function

YK Kim, OY Kim, J Song - Frontiers in Pharmacology, 2020 - frontiersin.org
Depression has emerged as a major cause of mortality globally. Many studies have reported
risk factors and mechanisms associated with depression, but it is as yet unclear how these …

Temporal discounting as a candidate behavioral marker of obesity

WK Bickel, R Freitas-Lemos, DC Tomlinson… - Neuroscience & …, 2021 - Elsevier
Although obesity is a result of processes operating at multiple levels, most forms result from
decision-making behavior. The aim of this review was to examine the candidacy of temporal …

A comprehensive review on weight loss associated with anti-diabetic medications

F Haddad, G Dokmak, M Bader, R Karaman - Life, 2023 - mdpi.com
Obesity is a complex metabolic condition that can have a negative impact on one's health
and even result in mortality. The management of obesity has been addressed in a number of …

Clinical impact of liraglutide as a treatment of obesity

H Alruwaili, B Dehestani… - … advances and applications, 2021 - Taylor & Francis
Obesity is defined as a chronic, complex, relapsing disease characterized by excessive
adipose tissue. Obesity impacts an individual's health by increasing complications such as …

Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1

AD Martins, MP Monteiro, BM Silva, A Barros… - Toxicology and Applied …, 2019 - Elsevier
Obesity incidence has pandemic proportions and is expected to increase even further.
Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological …

Molecular mechanisms controlled by mTOR in male reproductive system

BP Moreira, PF Oliveira, MG Alves - International journal of molecular …, 2019 - mdpi.com
In recent years, the mammalian target of rapamycin (mTOR) has emerged as a master
integrator of upstream inputs, such as amino acids, growth factors and insulin availability …

[HTML][HTML] Advances in anti-obesity pharmacotherapy: current treatments, emerging therapies, and challenges

S Brandfon, A Eylon, D Khanna, MS Parmar - Cureus, 2023 - ncbi.nlm.nih.gov
Obesity is a major public health concern linked to health risks such as hypertension,
hyperlipidemia, type 2 diabetes mellitus (T2DM), stroke, metabolic syndrome, asthma, and …